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α-C–H borylation of secondary alcohols via Ru/Fe relay catalysis: building a platform for alcoholic C–H/C–O functionalizations

Author:
Zhu, Qing, He, Zeyu, Wang, Lu, Hu, Yue, Xia, Chungu, Liu, Chao
Source:
Chemical communications 2019 v.55 no.79 pp. 11884-11887
ISSN:
1364-548X
Subject:
alcohols, carbon-hydrogen bond activation, catalysts, catalytic activity, chemical bonding, chemoselectivity, dehydrogenation, moieties, ruthenium
Abstract:
An unprecedented α-C–H borylation of secondary alcohols was successfully achieved and delivered various tertiary α-boryl alcohols via [Ru]/[Fe] relay catalysis. The dehydrogenation catalyst (Ru) and borylation catalyst (Fe) interacted to increase the chemoselectivity. By installing the “platform functional group” Bpin via this α-C–H borylation, several alcoholic α-C–H and C–O bond functionalizations were successfully achieved.
Agid:
6713931