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First total synthesis of versicotide D and analogs

Author:
Posada, Laura, Serra, Gloria
Source:
Tetrahedron letters 2019
ISSN:
0040-4039
Subject:
Plasmodium falciparum, amino acids, antimalarials, antiplasmodial properties, chemical reactions, chemical structure, organic compounds, peptides
Abstract:
The first total synthesis of cyclotetrapeptide versicotide D has been achieved in 21% overall yield using solid phase peptide synthesis and solution cyclization. In addition, in the search for candidates of antimalarial new drugs, one cyclic tetrapeptide analog which differs in the sequence, and four cyclic pentapeptide containing N-methyl amino acids, were prepared. The obtained compounds were evaluated against P. falciparum 3D7. Versicotide D showed low micromolar antiplasmodial activity.
Agid:
6729760