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First Cp*Co(III)-Catalyzed Mizoroki-Heck Coupling Reactions of Alkenes and Aryl bromide/Iodide

Author:
Srivastava, Avinash K., Satrawala, Naveen, Ali, Munsaf, Sharma, Charu, Joshi, Raj K.
Source:
Tetrahedron letters 2019
ISSN:
0040-4039
Subject:
acrylates, alkenes, catalysts, catalytic activity, chemical bonding, chemical structure, cobalt, cross-coupling reactions, organobromine compounds, organoiodine compounds, oxidation, styrene
Abstract:
A Cp*Co(CO)I2 catalyzed Mizoroki-Heck coupling of alkenes and aryl halide is established at feasible reaction conditions. The Cp*Co(III) catalyst excellently work to couple the aryl iodide and alkene, and produce up to 94% yield of the coupling product. In case of the coupling of aryl bromide and alkene, slightly reduced activity of the catalyst was observed, and moderate to good yield of the product was obtained. Apart from functionally different styrene, the catalyst was also able to activate the acrylates, which seems difficult to be activated by other reported metal complexes. The coupling proposed herein is tolerant a wide variety of aryl halides, stryenes, and acrylates enable to form C-C bond using inexpensive metal in catalysis. Hence, the present catalyst is highly economical, consists a non-endangered metal and is highly efficient for Heck coupling reaction. Moreover, the cobalt metal in high oxidation state (+3) is not much explored for the C-C cross-coupling reactions.
Agid:
6729762