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Silver-mediated oxidative 1,2-alkylesterification of styrenes with nitriles and acids via C(sp³)–H functionalization

Author:
Jiang, Shuai-Shuai, Wu, Yan-Chen, Luo, Shu-Zheng, Teng, Fan, Song, Ren-Jie, Xie, Ye-Xiang, Li, Jin-Heng
Source:
Chemical communications 2019 v.55 no.85 pp. 12805-12808
ISSN:
1364-548X
Subject:
alkenes, amino acids, aromatic compounds, carbon-hydrogen bond activation, carboxylic acids, catalysts, catalytic activity, chemical reactions, nickel, nitriles
Abstract:
A new silver-mediated 1,2-alkylesterification of alkenes with nitriles and acids promoted by a catalytic amount of nickel catalyst for producing acyloxylated nitriles has been developed via a C(sp³)–H functionalization process. By employing the NiI₂ and Ag₂CO₃ catalytic systems, the method features broad substrate scope with respect to carboxylic acids, including linear alkyl acids, cyclic acids, aryl acids and amino acids.
Agid:
6740690