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Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

Author:
Salehi, Bahare, López, Maria Dolores, Martínez‐López, Sara, Victoriano, Montserrat, Sharifi‐Rad, Javad, Martorell, Miquel, F. Rodrigues, Célia, Martins, Natália
Source:
Phytotherapy research 2019 v.33 no.11 pp. 2904-2917
ISSN:
0951-418X
Subject:
Stevia rebaudiana, antineoplastic activity, antioxidants, chemical composition, chemical constituents of plants, clinical trials, glycemic effect, human health, sucrose, therapeutics, Paraguay
Abstract:
Stevia rebaudiana Bertoni, a plant from South America and indigenous of Paraguay, has shown several biological effects and healthy properties, although it is especially used in South America and some Asiatic regions. In addition, it is a natural sweetener, almost 300 times sweeter than sucrose, being attributed to its phytoconstituents prominent antioxidant, antimicrobial, antidiabetic (antihyperglycemic, insulinotropic, and glucagonostatic), antiplatelet, anticariogenic, and antitumor effects. In this sense, this work aims to provide an extensive overview on the historical practices of stevia and its effects in human health based on its chemical composition and applications for both food and pharmaceutical industries.
Agid:
6752022