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False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia
- Borges, Moara Alves Santa Bárbara, Araújo Filho, João Alves de, Soares, Renata de Bastos Ascenço, Vidal, José Ernesto, Turchi, Marília Dalva
- Medical mycology case reports 2019 v.26 pp. 64-66
- Cryptococcus neoformans, HIV infections, antigens, blood serum, case studies, cerebrospinal fluid, clinical examination, false negative results, mycoses, patients
- The detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Careful clinical evaluation and close follow-up are relevant.