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Copper(I) catalysed direct synthesis of 2-methylene-4-chromanols
- Sarkar, Debayan, Behera, Sagarika
- Tetrahedron letters 2019
- alkynes, catalytic activity, chemical reactions, chemical structure, copper
- A copper catalyzed atom-economic synthesis of 2-methylene-4-chromanols has been described. The 2-methylene-4-chromanols act as an important entry points to a large section of biologically active motifs. The reaction delivers a wide substrate scope with moderate to excellent yields with substituted alkynes and in presence of unprotected alcoholic functionalities to deliver the 2-(2-hydroxy alkylidene)chroman-4-ols.