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Malacinones A and B, two novel sesquiterpenoids with 6/6/5 tricyclic ring system from the agarwood of Aquilaria malaccensis

Author:
Ma, Chi Thanh, Cho, Eunji, Nguyen, Huy Truong, Wu, Bo, Le, Thi Hong Van, Oh, Ki Bong, Kwon, Sung Won, Nguyen, Minh Duc, Park, Jeong Hill
Source:
Tetrahedron letters 2019 pp. 151355
ISSN:
0040-4039
Subject:
Aquilaria malaccensis, biochemical pathways, chemical reactions, chemical structure, circular dichroism spectroscopy, nuclear magnetic resonance spectroscopy, sesquiterpenoids, spectral analysis
Abstract:
Two novel cadinane-type sesquiterpenoids, named as malacinones A (1) and B (2), with an unprecedented tricyclic 6/6/5 ring system have been isolated from the agarwood of Aquilaria malaccensis. Their structures were elucidated by the various spectroscopic data (IR, MS, 1D, and 2D NMR) analysis and the absolute configurations were determined by the electronic circular dichroism (ECD) spectroscopic data analysis. A plausible biosynthetic pathway of malacinones A and B was proposed.
Agid:
6754616