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Determination of lead in dietary supplements by high-resolution continuum-source graphite furnace atomic absorption spectrometry with direct solid sampling

Author:
Leal, Gabriela Camera, Mattiazzi, Patricia, Rovasi, Franciele, Molin, Thaís Dal, Bohrer, Denise, do Nascimento, Paulo Cícero, de Carvalho, Leandro M., Viana, Carine
Source:
Subtropical plant science 2020 v.86 pp. 103360
ISSN:
0889-1575
Subject:
atomic absorption spectrometry, detection limit, dietary supplements, lead, magnesium, nitrates, zirconium
Abstract:
A method has been developed for the determination of lead (Pb) in dietary supplements using direct solid sampling and high-resolution continuum source graphite furnace atomic absorption spectrometry. The lead concentration was determined in 74 food supplements. The zirconium (Zr) coated platform, and chemical modifiers [Pd(NO₃)₂ and Mg(NO₃)₂] were applied. Mass aliquots between 0.8 and 1.0 mg were weighed and directly inserted into the graphite furnace. The precision (expressed as RSD) was lower than 5%, and a detection limit of 2.16 pg was obtained at the 283.306 nm resonance line. The limit of quantification was 7.2 pg. The Pb recuperation in the standard reference material, Bitter Orange-Containing Solid Oral Form NIST SRM 3260, was 116% of the certified value. The contents of Pb in the dietary supplement samples varied in the 0.04–25.3 μg/day range. Two samples had results above that allowed by American Pharmacopoeia for inorganic analysis in food supplements.
Agid:
6755924