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Unfavorable effect of type 1 and type 2 diabetes on maternal and fetal essential fatty acid status: a potential marker of fetal insulin resistance

Author:
Min, Yoeju, Lowy, Clara, Ghebremeskel, Kebreab, Thomas, Beverley, Offley-Shore, Brigid, Crawford, Michael
Source:
American journal of clinical nutrition 2005 v.82 no.6 pp. 1162-1168
ISSN:
0002-9165
Subject:
maternal nutrition, pregnant women, pregnancy, insulin-dependent diabetes mellitus, noninsulin-dependent diabetes mellitus, maternal effect, maternal-fetal transfer, fetus, free fatty acids, arachidonic acid, docosahexaenoic acid, insulin resistance, biomarkers, blood lipids, umbilical cord
Abstract:
BACKGROUND: Pregestational maternal diabetes increases obesity and diabetes risks in the offspring. Both conditions are characterized by insulin resistance, and diabetes is associated with low membrane arachidonic (AA) and docosahexaenoic (DHA) acids. OBJECTIVE: We investigated whether type 1 and type 2 diabetes in pregnancy compromise maternal and fetal membrane essential fatty acids (FAs). DESIGN: We studied 39 nondiabetic (control subjects), 32 type 1 diabetic, and 17 type 2 diabetic pregnant women and the infants they delivered. Maternal and cord blood samples were obtained at midgestation and at delivery, respectively. Plasma triacylglycerols and choline phosphoglycerides and red blood cell (RBC) choline and ethanolamine phosphoglyceride FAs were assessed. RESULTS: The difference in maternal plasma triacylglycerol FAs between groups was not significant. However, the type 1 diabetes group had lower plasma choline phosphoglyceride DHA (3.7 ± 0.9%; P < 0.01) than did the control group (5.2 ± 1.6%). Likewise, RBC DHA was lower in the type 1 [choline: 3.4 ± 1.5% (P < 0.01); ethanolamine: 5.9 ± 2.5% (P < 0.05)] and type 2 [choline: 3.5 ± 1.6% (P < 0.05)] diabetes groups than in the control group (choline: 5.5 ± 2.2%; ethanolamine: 7.5 ± 2.5%). Cord AA and DHA were lower in the plasma (type 1: P < 0.01) and RBC (type 2: P < 0.05) choline phosphoglycerides of the diabetics than of the control subjects, and cord RBC ethanolamine phosphoglycerides were lower in DHA (P < 0.05) in both diabetes groups than in the control group. CONCLUSIONS: Diabetes (either type) compromises maternal RBC DHA and cord plasma and RBC AA and DHA. The association of these 2 FAs with insulin sensitivity may mean that the current finding explains the higher incidence of insulin resistance and diabetes in the offspring of diabetic women.
Agid:
680116