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Plant-made HIV vaccines and potential candidates
- Tremouillaux-Guiller, Jocelyne, Moustafa, Khaled, Hefferon, Kathleen, Gaobotse, Goabaone, Makhzoum, Abdullah
- Current opinion in biotechnology 2020 v.61 pp. 209-216
- Human immunodeficiency virus 1, animal models, broadly neutralizing antibodies, coat proteins, epitopes, glycoproteins, neutralization, recombinant proteins, secondary infection, therapeutics, vaccines
- Millions of people around the world suffer from heavy social and health burdens related to HIV/AIDS and its associated opportunistic infections. To reduce these burdens, preventive and therapeutic vaccines are required. Effective HIV vaccines have been under investigation for several decades using different animal models. Potential plant-made HIV vaccine candidates have also gained attention in the past few years. In addition to this, broadly neutralizing antibodies produced in plants which can target conserved viral epitopes and neutralize mutating HIV strains have been identified. Numerous epitopes of envelope glycoproteins and capsid proteins of HIV-1 are a part of HIV therapy. Here, we discuss some recent findings aiming to produce anti-HIV-1 recombinant proteins in engineered plants for AIDS prophylactics and therapeutic treatments.