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Rhodium catalyzed direct C3-ethoxycarbonylmethylation of imidazo[1,2-a]pyridines with ethyl diazoacetate

Author:
Huang, Qiuyao, Dong, Hui, Li, Bingbing, Hu, Wenhao, Wang, Yuanxiang
Source:
Tetrahedron 2020 v.76 no.10 pp. 130998
ISSN:
0040-4020
Subject:
antineoplastic agents, catalysts, catalytic activity, chemical reactions, chemical structure, pyridines, rhodium
Abstract:
An efficient and environment-friendly C3-ethoxycarbonylmethylation of imidazo[1,2-a]pyridines with ethyl diazoacetate in the presence of a Rh(II) catalyst was developed. Such strategy not only enables the synthesis of zolpidem, but also provides a way to generate synthetic intermediates to afford cellular active anticancer agents.
Agid:
6834561