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HER2 targeted biological macromolecule modified liposomes for improved efficacy of capecitabine in breast cancer
- Singh, Mantosh Kumar, Pindiprolu, Sai Kiran S.S., Sanapalli, Bharat Kumar Reddy, Yele, Vidyasrilekha, Ganesh, G.N.K.
- International journal of biological macromolecules 2020 v.150 pp. 631-636
- antineoplastic activity, breast neoplasms, chitosan, cytotoxicity, mice, oligopeptides, receptors, remission
- The present research reports the beneficial effects of surface modified chitosan and tumor-homing peptide conjugated liposomes of capecitabine (CAP) for treating breast cancer. Liposomal formulation of CAP was prepared by film hydration method using cholesterol-THP conjugate (CTHP-CAP-LPs) to achieve active targeting through HER2 receptors. CTHP-CAP-LPs significantly improved the specificity and efficacy of CAP by improving cell uptake, cytotoxicity and tumor regression in tumor bearing mice. CTHP-CAP-LPs, therefore, is a promising approach to improve the anticancer effects of CAP.