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Polyphenols and Intestinal Permeability: Rationale and Future Perspectives

Author:
Bernardi, Stefano, Del Bo’, Cristian, Marino, Mirko, Gargari, Giorgio, Cherubini, Antonio, Andrés-Lacueva, Cristina, Hidalgo-Liberona, Nicole, Peron, Gregorio, González-Dominguez, Raúl, Kroon, Paul, Kirkup, Benjamin, Porrini, Marisa, Guglielmetti, Simone, Riso, Patrizia
Source:
Journal of agricultural and food chemistry 2019 v.68 no.7 pp. 1816-1829
ISSN:
1520-5118
Subject:
bioactive compounds, diet, environmental factors, in vivo studies, intestines, permeability, polyphenols
Abstract:
Increasing evidence links intestinal permeability (IP), a feature of the intestinal barrier, to several pathological or dysfunctional conditions. Several host and environmental factors, including dietary factors, can affect the maintenance of normal IP. In this regard, food bioactives, such as polyphenols, have been proposed as potential IP modulators, even if the mechanisms involved are not yet fully elucidated. The aim of the present paper is to provide a short overview of the main evidence from in vitro and in vivo studies supporting the role of polyphenols in modulating IP and briefly discuss future perspectives in this research area.
Agid:
6843887