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Evidence on correlation between number of disulfide bridge and toxicity of class IIa bacteriocins

Author:
Richard, C., Canon, R., Naghmouchi, K., Bertrand, D., Prevost, H., Drider, D.
Source:
Food microbiology 2006 v.23 no.2 pp. 175-183
ISSN:
0740-0020
Subject:
lactic acid bacteria, starter cultures, secondary metabolites, bacteriocins, antibacterial proteins, physicochemical properties, signal peptide, disulfide bonds, heat stability, molecular weight, antibacterial properties, mathematical models, culture media, food preservatives, medical treatment
Abstract:
The aim of this work was to study in the same microbiological conditions and for the first time the inhibitory action of eight class IIa bacteriocins against 23 Gram-positive bacteria in which some of them are industrially used as starters and against the eight class IIa bacteriocins producing strains themselves. The sensitivity of each strain was determined after MPA using the mathematical model described by Cabo et al. (1999, J. Appl. Microbiol. 87, 907-914). Therefore, the principal component analysis realized led to a strong correlation between spectrum and extra-disulfide bridge and a minor correlation between spectrum and isoelectric point of each bacteriocin.
Agid:
684685