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Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway
- Chaves, Fernanda Machado, Pavan, Isadora Carolina Betim, da Silva, Luiz Guilherme Salvino, de Freitas, Lidia Broglio, Rostagno, Mauricio Ariel, Antunes, Adriane Elisabete Costa, Bezerra, Rosângela Maria Neves, Simabuco, Fernando Moreira
- Plant foods for human nutrition 2020 v.75 no.1 pp. 54-62
- Punica granatum, antimicrobial properties, antineoplastic activity, byproducts, cell lines, food industry, fruit extracts, fruits, medicine, men, neoplasm cells, peeling, polyphenols, pomegranate juice, pomegranates, prostatic neoplasms, signal transduction
- Pomegranate (Punica granatum) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and anti-microbial properties. It has been used in popular medicine for cancer treatment, which still represents the major cause of cancer-related deaths in men worldwide. Importantly, pomegranate peels are valuable by-products of the food industry that are rich in polyphenols. Here we report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. Besides, the growth-related mTOR/S6K signaling pathway presented strong inhibition after pomegranate extracts treatment. This study presents evidence that both juice and isolated peel extracts from promegate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway.