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Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway

Chaves, Fernanda Machado, Pavan, Isadora Carolina Betim, da Silva, Luiz Guilherme Salvino, de Freitas, Lidia Broglio, Rostagno, Mauricio Ariel, Antunes, Adriane Elisabete Costa, Bezerra, Rosângela Maria Neves, Simabuco, Fernando Moreira
Plant foods for human nutrition 2020 v.75 no.1 pp. 54-62
Punica granatum, antimicrobial properties, antineoplastic activity, byproducts, cell lines, food industry, fruit extracts, fruits, medicine, men, neoplasm cells, peeling, polyphenols, pomegranate juice, pomegranates, prostatic neoplasms, signal transduction
Pomegranate (Punica granatum) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and anti-microbial properties. It has been used in popular medicine for cancer treatment, which still represents the major cause of cancer-related deaths in men worldwide. Importantly, pomegranate peels are valuable by-products of the food industry that are rich in polyphenols. Here we report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. Besides, the growth-related mTOR/S6K signaling pathway presented strong inhibition after pomegranate extracts treatment. This study presents evidence that both juice and isolated peel extracts from promegate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway.