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Taurine increases cholesterol 7α-hydroxylase activity and fecal bile acids excretion but does not reduce the plasma cholesterol concentration in ovariectomized rats fed with coconut oil
- Ebihara, K., Miyazato, S., Ogawa, H., Kishida, T.
- Nutrition research 2006 v.26 no.4 pp. 167-172
- rats, animal models, ovariectomy, hormones, hypercholesterolemia, dietary fat, coconut oil, coconuts, taurine, saturated fatty acids, cholesterol metabolism, cholesterol 7alpha-monooxygenase, enzyme activity, blood lipids, cholesterol, low density lipoprotein, receptors, feces, bile acids
- We studied the effect of taurine on ovarian hormone deficiency-induced hypercholesterolemia in 6-month-old, ovariectomized rats fed with coconut oil. Rats were fed 1 of 4 diets for 28 days: purified diet based on coconut oil without or with taurine (10, 30, or 50 g/kg, called the C, 10T, 30T and 50T diets, respectively). Coconut oil is rich in lauric and myristic acids, which are saturated fatty acids that reduce the level of hepatic low-density lipoprotein receptor activity. Plasma cholesterol level was not affected by the diet. The low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels in the liver increased by feeding the 50T diet compared with the C diet. As the dietary level of taurine increased, the levels of cholesterol 7α-hydroxylase activity, and fecal bile acids excretion logarithmically increased. Our results showed that taurine increased fecal bile acids excretion but did not prevent ovarian hormone deficiency-induced hypercholesterolemia in rats fed with coconut oil.