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A new prenylated coumarin and a new anthranilamide derivative from Evodia lepta

Author:
Xie, Xing-Lin, Ye, Guo-Hua, Xue, Jun-Juan, Su, Tong, Tang, Gui-Hua, Li, Wei, Yin, Sheng
Source:
Journal of Asian natural products research 2020 v.22 no.5 pp. 413-417
ISSN:
1477-2213
Subject:
Euodia, aerial parts, coumarin, inhibitory concentration 50, lipopolysaccharides, macrophages, nitric oxide, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
A new prenylated coumarin (1) and a new anthranilamide derivative (2) were isolated from the aerial parts of Evodia lepta. Compound 2 represents the first anthranilamide derivative from the Evodia genus. Their structures were elucidated by spectroscopic data analysis (MS, UV, IR, and NMR). Compound 1 exhibited certain inhibition on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages with an IC₅₀ value of 37.96 ± 1.7 μM.
Agid:
6863161