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Boosting Cytotoxic Antibodies against Cancer
- Gauthier, Laurent, Vivier, Eric
- Cell 2020 v.180 no.5 pp. 822-824
- antigens, cytotoxicity, drugs, monoclonal antibodies, neoplasm cells, neoplasms
- Monoclonal antibodies (mAbs) targeting antigens expressed at the surface of tumor cells are widely used for cancer control in clinics, but these treatments need to be improved. Chew et al. show how an old drug, prochlorperazine, could be repurposed to enhance the efficacy of anti-tumor mAbs by increasing the cell-surface expression of tumor antigens.