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Taxonomic identification and bioactive compounds characterization of Psilocybe cubensis DPT1 to probe its antibacterial and mosquito larvicidal competency

Dharumadhurai Dhanasekaran, Selvanathan Latha, Packkrisamy Suganya, Annamalai Panneerselvam, Thiruppathi Senthil Kumar, Naiyf S. Alharbi, Chinnathambi Arunachalam, Sulaiman Ali Alharbi, Nooruddin Thajuddin
Microbial pathogenesis 2020 v.143 pp. 104138
Culex quinquefasciatus, Proteus vulgaris, Psilocybe, alkaloids, analytical methods, antibacterial properties, bioactive compounds, biological control, chemical constituents of plants, ethyl acetate, flavonoids, genetic markers, humans, larvicides, mushrooms, plants (botany), saponins, species identification, tannins, traditional medicine, India
Mushrooms have an important role in sustainability since they have long been used as valuable food source and traditional medicine around the world. Regrettably, they are among the most rigorously affected populations, along with several plants and animals, due to the destructive activities of mankind. Thus the authentication and conservation of mushroom species are constantly needed to exploit the remarkable potential in them. In this perspective, an attempt has been made to identify and assess the biological attributes of psychedelic mushrooms collected from Kodaikanal, Tamil Nadu, India. The macromorphological features of the psychedelic mushroom DPT1 helped its presumptive identification and the molecular characters depicted by DNA marker revealed its close relationship with the genus Psilocybe. Accordingly, the psychedelic mushroom was identified as Psilocybe cubensis DPT1 and its crude ethyl acetate extract on analysis revealed the occurrence of phytoconstituents like alkaloids, flavonoids, tannins, saponins and carbohydrates. Moreover, it exhibited 80% larvicidal activity against Culex quinquefasciatus mosquito at 800 ppm concentration and an array of antibacterial effects with utmost susceptibility of Proteus vulgaris, and the identification of bioactive compounds by different analytical techniques substantiate that the bioactivities might be due to the presence of phytochemicals. The results of the study indicated that the extract of P. cubensis DPT1 having notable antibacterial and mosquito larvicidal efficacies which could be probed further for the isolation of medicinally important as well as bio-control compounds.