Jump to Main Content
Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
- Đurašević, Siniša, Nikolić, Gorana, Todorović, Ana, Drakulić, Dunja, Pejić, Snežana, Martinović, Vesna, Mitić-Ćulafić, Dragana, Milić, Dragana, Kop, Tatjana J., Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran
- Food and chemical toxicology 2020 v.140 pp. 111302
- DNA, adrenal glands, advanced oxidation protein products, alanine transaminase, alkaline phosphatase, aorta, aspartate transaminase, bacteria, bioaccumulation, biotransformation, blood serum, brain, coconut oil, fullerene, glucose, heart, hepatocytes, histology, homeostasis, insulin resistance, intestinal microorganisms, kidneys, liver, malondialdehyde, olives, oxidation, physicochemical properties, rats, small intestine, spleen, tissues, triacylglycerols
- The effects of twelve weeks of supplementation with fullerene C₆₀ olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C₆₀ was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C₆₀ did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C₆₀ significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C₆₀ on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C₆₀ aggregation or biotransformation as the key element of its pro-oxidative action.