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Imprinted Small RNAs Unraveled: Maternal MicroRNAs Antagonize a Paternal-Genome-Driven Gene Expression Network
- Ghousein, Amani, Feil, Robert
- Molecular cell 2020 v.78 no.1 pp. 3-5
- gene expression, gene expression regulation, genes, genomic imprinting, microRNA, neurons
- Whipple et al., 2020 describe that, in neurons, a dense cluster of maternally expressed microRNAs post-transcriptionally downregulates several imprinted genes expressed from the paternal genome—an antagonistic mechanism that modulates neuronal functions and provides insights into the evolution of genomic imprinting.