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Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection
- An, Tong-Qing, Li, Jiang-Nan, Su, Chia-Ming, Yoo, Dongwan
- Virus research 2020 v.286 pp. 197980
- Porcine reproductive and respiratory syndrome virus, apoptosis, cytokines, financial economics, innate immunity, microRNA, pathogenesis, pork industry
- Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for modulations of cellular processes including innate immunity, apoptosis, microRNAs, inflammatory cytokines, and other cellular pathways.