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Spot the Difference: Function versus Toxicity in Amyloid Fibrils
- Ulamec, Sabine M., Radford, Sheena E.
- Trends in biochemical sciences 2020 v.45 no.8 pp. 635-636
- Alzheimer disease, Drosophila, amyloid, brain, cryo-electron microscopy, memory, toxicity
- In a recent study, Hervas et al. extracted Orb2 fibrils, that are involved in long-term memory formation, from Drosophila brains, characterised their function, and determined their structure using cryo-electron microscopy (cryo-EM). The fibrils show a remarkable resemblance to amyloid β (Aβ) fibrils associated with Alzheimer’s disease, highlighting the subtle difference between functional and dysfunctional amyloid.