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Rapid degradation of gliadin peptides toxic for coeliac disease patients by proteases from germinating cereals

Author:
Hartmann, G., Koehler, P., Wieser, H.
Source:
Journal of cereal science 2006 v.44 no.3 pp. 368-371
ISSN:
0733-5210
Subject:
degradation, gliadin, peptides, celiac disease, patients, proteinases, germination, wheat, rye, barley, detoxification (processing), toxins, gluten-free foods, gluten
Abstract:
We report the isolation and characterisation of proteases from germinated wheat, rye and barley, and their ability to degrade gliadin peptides toxic for coeliac patients. It is shown for the first time that these proteases cleave these peptides rapidly into non-toxic fragments with less than nine amino acids. These proteases have distinct advantages when compared to bacterial or fungal proteases, and are promising candidates for the detoxification of gluten containing foods and for oral therapy for celiac patients.
Agid:
695640