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Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract
- Shu, X.S., Gao, Z.H., Yang, X.L.
- Journal of ethnopharmacology 2006 v.103 no.3 pp. 327-332
- Smilax, medicinal plants, tubers, chemical constituents of plants, plant extracts, medicinal properties, anti-inflammatory activity, analgesic effect, bioassays, rats, mice, traditional medicine, ethnobotany, China
- The aqueous extract of the tuber of Smilax china L., popularly known in China as “Jin Gang Ten”, was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively. The aqueous extract in the dose of 1000 mg/kg (i.g.) had a significant anti-nociceptive and anti-inflammatory effect compared to physiological saline. The anti-inflammatory effects are similar to acetylsalicylic acid (200 mg/kg, i.g.). We also evaluated the aqueous extract for the inhibition of prostaglandin production (for COX-2 inhibitions) in lipopolysaccharide (LPS)-induced mouse macrophage cells. The result showed that both COX-2 activity and COX expression were inhibited by the extract. These active extracts suppressing activities warranted further studies of active principles and development of new anti-inflammatory and analgesic agents. Studies to determine correlation between chemical composition and pharmacological activity are underway.