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Bacterial cellulose matrix with in situ impregnation of silver nanoparticles via catecholic redox chemistry for third degree burn wound healing
- Jiji, Swaminathan, Udhayakumar, Sivalingam, Maharajan, Kannan, Rose, Chellan, Muralidharan, Chellappa, Kadirvelu, Krishna
- Carbohydrate polymers 2020 v.245 pp. 116573
- albino, angiogenesis, antimicrobial properties, burns (injuries), cell proliferation, cellulose, collagen, cytotoxicity, females, gene expression, genes, histopathology, in vivo studies, laboratory animals, nanocomposites, nanosilver, pathogens, physicochemical properties, rats, tissue repair, wound treatment
- In the present study, bacterial cellulose (BC) based nanocomposite dressing material was developed for third burn wound management by polydopamine (PD) coated BC with in situ reduction of silver nanoparticles (BC-PDAg). BC-PDAg nanocomposite was characterized to understand the morphological, physical and chemical properties. Antimicrobial activity of BC-PDAg against burn wound specific pathogens were significant. The in vitro cytotoxicity and proliferation studies revealed that BC-PDAg nanocomposite is biocompatible and it supports cell proliferation. Further, in vivo experiments on female albino Wistar rats confirmed that BC-PDAg was effective in wound healing by promoting re-epithelization, and collagen deposition as evidenced by histopathological analysis. Moreover, molecular gene expression study has revealed that BC-PDAg promotes healing process by regulating the expression of inflammatory, angiogenesis and growth factor genes. The overall performance of BC-PDAg nanocomposite suggests that it could be used as promising skin regenerative tool in modern medicine.