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Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol

Author:
Sugawara, T., Matsubara, K., Akagi, R., Mori, M., Hirata, T.
Source:
Journal of agricultural and food chemistry 2006 v.54 no.26 pp. 9805-9810
ISSN:
0021-8561
Subject:
Undaria pinnatifida, edible seaweed, carotenoids, medicinal properties, cell proliferation, cell growth, blood vessels, endothelial cells, blood veins, cell differentiation, aorta, rats, cell lines
Abstract:
The antiangiogenic effects of fucoxanthin and a deacetylated product, fucoxanthinol, were examined. Fucoxanthin significantly suppressed HUVEC proliferation and tube formation at more than 10 micromolar, but it had no significant effect on HUVEC chemotaxis. The formation of blood vessel-like structures from CD31-positive cells was evaluated using embryonic stem cell-derived embryoid bodies. Fucoxanthin effectively suppressed the development of these structures at 10-20 micromolar, suggesting that it could suppress differentiation of endothelial progenitor cells into endothelial cells involving new blood vessel formation. Fucoxanthin and fucoxanthinol suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring, in a dose-dependent manner. These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases.
Agid:
699283