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Alterations in plasma antioxidants during reperfusion of the ischemic small intestine in rats

Author:
Papezikova, I., Lojek, A., Cizova, H., Ciz, M.
Source:
Research in veterinary science 2006 v.81 no.1 pp. 140-147
ISSN:
0034-5288
Subject:
rats, small intestine, ischemia, blood chemistry, blood plasma, antioxidants, blood flow, serum albumin, uric acid, free radicals, free radical scavengers, thiobarbituric acid-reactive substances, lipid peroxidation, oxidative stress
Abstract:
The aim of this study was to evaluate the contribution of three plasma antioxidants (albumin, uric acid, SH groups) to the plasma total peroxyl radical-trapping antioxidant capacity (TRAP) in 2 and 4 h of intestinal reperfusion in rats. TRAP increased significantly both after 2 and 4 h of reperfusion. Neither albumin nor SH groups contributed significantly to this increase. TRAP was strongly influenced by the increase in uric acid concentration and also probably by the cell destruction caused by oxidative stress. Since the TRAP increase was accompanied by an increase in the level of thiobarbituric acid reactive substances (TBARS, a marker of lipid peroxidation), we can conclude that even such a large increase in TRAP is not sufficient to prevent the progression of lipid peroxidation and oxidative stress.
Agid:
699912