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Secondary metabolites of Rubus caesius (Rosaceae)
- Grochowski, Daniel M., Strawa, Jakub W., Granica, Sebastian, Tomczyk, Michał
- Biochemical systematics and ecology 2020 v.92 pp. 104111
- Rubus, blackberries, diarrhea, ellagic acid, hyperglycemia, inflammation, kaempferol, leaves, liquid chromatography, mass spectrometry, phenolic acids, quercetin, secondary metabolites, shrubs, traditional medicine, Europe, North America
- The European dewberry (Rubus caesius) is a perennial shrub that is widely distributed in Europe but can also be found in North America. In folk medicine, the European dewberry is used to treat hyperglycaemia, diarrhoea and inflammation. LC-MS analysis of the European dewberry confirmed the presence of 35 compounds, mostly flavonoids, phenolic acids and derivatives of ellagic acid. Phytochemical analysis of R. caesius leaves led to the isolation of nine phenolics, namely: quercetin 3-O-β-D-rutinoside (1), kaempferol 3-O-β-D-glucuronide (2), quercetin 3-O-β-D-glucuronide (3), methyl brevifolincarboxylate (4), kaempferol 3-O-β-D-(6″-O-(E)-p-coumaroyl)-glucoside (5), kaempferol (6), quercetin (7), pedunculagin (8), and ellagic acid (9). Compounds 1–8 were isolated from this species for the first time. The chemophenetic significance was discussed.