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Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis

Author:
COX, S.K.
Source:
Journal of veterinary pharmacology and therapeutics 2007 v.30 no.5 pp. 381-386
ISSN:
0140-7783
Subject:
quinolones, pharmacokinetics, half life, drug excretion, tissue distribution, volume, body weight, prediction, probability analysis, equations, species differences
Abstract:
The purpose of this study was to examine the allometric analyses of marbofloxacin, moxifloxacin, danofloxacin and difloxacin using pharmacokinetic data from the literature. The parameters of interest (half-life, clearance and volume of distribution) were correlated across species as a function of body weight using an allometric approach (Y = aWb). Results of the allometric analysis indicated similarity between clearance and volume of distribution as they relate to body weight for all drugs. The elimination half-life was independent of body mass for all fluoroquinolones except moxifloxacin. Results of the analysis suggest that allometric scaling can be used as a tool for predicting pharmacokinetic parameters for fluoroquinolones.
Agid:
710205