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Antioxidant activity of stilbene glycoside from Polygonum multiflorum Thunb in vivo

Author:
Lv, L., Gu, X., Tang, J., Ho, C.T.
Source:
Food chemistry 2007 v.104 no.4 pp. 1678-1681
ISSN:
0308-8146
Subject:
in vivo studies, stilbenes, oxidative stress, superoxide dismutase, plant extracts, glutathione peroxidase, animal models, rats, antioxidant activity, roots, enzyme activity, thiobarbituric acid-reactive substances, Reynoutria multiflora
Abstract:
Stilbene glycosides were isolated from the ethanol extract of the roots of Polygonum multiflorum Thunb. Two samples were obtained; a fraction separated by macroporous resin and pure crystals of 2,3,5,4'-tetrahydroxystilbene 2-O-β-glucopyranoside. The antioxidant activities of these two samples were evaluated using antioxidant tests of rats in vivo. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of the serum and the organs (liver, heart and brain of rats) of d-galactose induced senile rats which were fed with stilbene glycoside, were increased; however, the content of 2-thiobarbituric acid-reactive substances (TBARS) was decreased. It is concluded that the stilbene glycoside from Polygonum multiflorum Thunb possesses high in vivo antioxidant activity.
Agid:
712310