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Cranial mediastinal carcinomas in nine dogs

Liptak, J.M., Kamstock, D.A., Dernell, W.S., Ehrhart, E.J., Rizzo, S.A., Withrow, S.J.
Veterinary and comparative oncology 2008 v.6 no.1 pp. 19-30
embolism, drug therapy, mediastinum, dog diseases, dogs, carcinoma, resection, metastasis, thyroid gland, excision, lungs, vena cava, heart, radiotherapy, disease course, disease diagnosis
Nine dogs were diagnosed with cranial mediastinal carcinomas. Based on histological and immunohistochemical analysis, four dogs were diagnosed with ectopic follicular cell thyroid carcinomas, one dog with ectopic medullary cell thyroid carcinoma, two dogs with neuroendocrine carcinomas and two dogs with anaplastic carcinomas. Clinical signs and physical examination findings were associated with a space-occupying mass, although one dog was diagnosed with functional hyperthyroidism. Surgical resection was attempted in eight dogs. The cranial mediastinal mass was invasive either into the heart or into the cranial vena cava in three dogs. Resection was complete in six dogs and unresectable in two dogs. All dogs survived surgery, but four dogs developed pulmonary thromboembolism and two dogs died of respiratory complications postoperatively. Adjunctive therapies included pre-operative radiation therapy (n = 1) and postoperative chemotherapy (n = 3). Three dogs had metastasis at the time of diagnosis, but none developed metastasis following surgery. The overall median survival time was 243 days. Local invasion, pleural effusion and metastasis did not have a negative impact on survival time in this small case series.