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Frequencies of PRNP Gene Polymorphisms in Vietnamese Dairy Cattle for Potential Association with BSE
- Muramatsu, Y., Sakemi, Y., Horiuchi, M., Ogawa, T., Suzuki, K., Kanameda, M., Hanh, T.T., Tamura, Y.
- Zoonoses and public health 2008 v.55 no.5 pp. 267-273
- genes, genetic polymorphism, dairy cattle, bovine spongiform encephalopathy, zoonoses, cattle diseases, Vietnam
- Since 2004, significant associations between bovine spongiform encephalopathy (BSE) susceptibility in cattle and frequencies of insertion/deletion (ins/del; indel) polymorphisms within the bovine prion protein gene (PRNP) have been reported. In this study, we investigated the frequencies of indel polymorphisms within two variable sites, a 23-bp indel polymorphism in the promoter region (23indel) and a 12-bp indel polymorphism in intron 1 region (12indel), in the PRNP in 206 Vietnamese dairy cattle and seven Japanese BSE-affected cattle. In Vietnamese dairy cattle, the frequency distributions of del allele and del/del genotypic polymorphisms in the 23indel site, which are thought to be associated with BSE susceptibility, were significantly higher, whereas the frequencies of del allelic and del/del genotypic polymorphisms in the 12indel site, which have been reported to confer BSE susceptibility, were significantly lower. We have provided evidence that Vietnamese dairy cattle have a unique genetic background in the PRNP gene in comparison with cattle or sires previously reported in other countries.