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Quantification of glycoproteins by nuclear magnetic resonance associated with preclinical carotid atherosclerosis in patients with type 1 diabetes

Author:
Tonet Serés-Noriega, Marga Giménez, Verónica Perea, Jesús Blanco, Irene Vinagre, Adriana Pané, Sabina Ruiz, Monserrat Cofán, Alex Mesa, Enric Esmatjes, Ignacio Conget, Emilio Ortega, Antonio J. Amor
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.7 pp. 2099-2108
ISSN:
0939-4753
Subject:
C-reactive protein, age, atherosclerosis, biomarkers, drugs, evolution, glycoproteins, height, inflammation, insulin-dependent diabetes mellitus, kidney diseases, males, metabolism, nuclear magnetic resonance spectroscopy, nutrition, risk factors, thickness, ultrasonography, width
Abstract:
Glycoproteins play a key role in inflammatory and cardiometabolic processes. Their implication in atherosclerosis in type 1 diabetes (T1D) is unknown. We assessed the relationships between classic inflammatory markers, glycoproteins measured by nuclear magnetic resonance (¹H-NMR), and preclinical atherosclerosis in these patients.We selected patients with T1D, without cardiovascular disease (CVD), with: age ≥40 years, nephropathy (micro/macroalbuminuria), or ≥10 years of evolution with another risk factor. The presence of plaque (intima-media thickness >1.5 mm) was determined by ultrasonography. Concentrations of high-sensitive C-reactive protein (hsCRP), circulating leukocytes (classical inflammation markers) and ¹H-NMR-glycoproteins (GlycA, GlycB, GlycF, and the height/width [H/W] ratios of GlycA and GlycB) were determined. We included 189 patients (58% male, age 47.0 [40.7–55.2] years). Thirty-five percent presented plaques (22%, ≥2 plaques). There was no association between hsCRP or leukocytes and atherosclerosis. However, in age- and sex-adjusted models, GlycA, GlycF, and the H/W ratios of GlycA and GlycB gradually increased with the number of plaques (0, 1, ≥2 plaques) only in patients without statins (p < 0.05), with no association in patients receiving this drug (p for interaction <0.05; in ≥2 plaques). Finally, in models adjusted for other classical and T1D-specific risk factors, GlycA and GlycB H/W ratios remained associated with carotid plaque (OR 1.39 [1.12–1.90] and OR 6.89 [1.85–25.62], respectively).In T1D individuals without lipid-lowering treatment, ¹H-NMR-glycoproteins were independently associated with the presence and amount of carotid atherosclerosis, unlike other classical inflammatory markers. Further studies are needed to ascertain their utility as CVD biomarkers.
Agid:
7333945