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Hancornia speciosa: Indications of gastroprotective, healing and anti-Helicobacter pylori actions

Author:
Moraes, Thiago de Mello, Rodrigues, Clenilson Martins, Kushima, Hélio, Bauab, Tais Maria, Villegas, Wagner, Pellizzon, Cláudia Helena, Brito, Alba Regina Monteiro Souza, Hiruma-Lima, Clélia Akiko
Source:
Journal of ethnopharmacology 2008 v.120 no.2 pp. 161-168
ISSN:
0378-8741
Subject:
proanthocyanidins, Apocynaceae, medicinal plants, plant extracts, gastritis, gastric juice, stomach ulcers, protective effect, animal disease models, traditional medicine, antidiarrheal effect, Helicobacter pylori, antioxidant activity, anti-ulcer activity, gastric mucosa, pH, chemical constituents of plants, bark, rodents, Brazil
Abstract:
Ethnopharmacological relevance: Mangaba (Hancornia speciosa Gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of Brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomachache. Aim of the study: The hydroalcoholic extract (HE) and infusion (BI) of Hancornia speciosa bark were investigated for their ability to prevent and heal rodent gastric ulcer. Materials and methods: The preventive and healing action of both preparations of Hancornia speciosa were evaluated in experimental models in rodents that simulated this disease in human gastric mucosa. Results: BI did not exert gastroprotective effect, in contrast to HE (500mg/kg, p.o.) that decreased (p <0.05) the severity of gastric damage induced by HCl/ethanol (52%), indomethacin/bethanechol (51%), stress (52%) or pylorus ligature experiments (54%). HE increased (p <0.05) the pH and decreased acid output of gastric juice. This extract promoted increase of mucus amount (3.62mg/wt. tissue vs. 5.81mg/wt. tissue), healing action (67%) and displayed anti-Helicobacter pylori effect. Conclusions: The antiulcer action of Hancornia speciosa resulted in increase of gastric mucus formation and antioxidant properties of polymeric proanthocyanidins present in the bark composition of this medicinal plant.
Agid:
741746