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Potential anti-allergic acridone alkaloids from the roots of Atalantia monophylla

Author:
Chukaew, Arnon, Ponglimanont, Chanita, Karalai, Chatchanok, Tewtrakul, Supinya
Source:
Phytochemistry 2008 v.69 no.14 pp. 2616-2620
ISSN:
0031-9422
Subject:
Atalantia, medicinal plants, phytochemicals, alkaloids, chemical structure, spectral analysis, stereochemistry, hypersensitivity, human health
Abstract:
Acridone alkaloids, cycloatalaphylline-A (1), N-methylcyclo-atalaphylline-A (2) and N-methylbuxifoliadine-E (3), were isolated from the dichloromethane and acetone extracts of the root of Atalantia monophylla along with eight known acridone alkaloids: buxifoliadine-A (4), buxifoliadine-E (5), N-methylatalaphylline (6), atalaphylline (7), citrusinine-I (8), N-methylataphyllinine (9), yukocitrine (10) and junosine (11) and two known coumarins: auraptene (12) and 7-O-geranylscopoletin (13). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 2, 5 and 8 possessed appreciable anti-allergic activity in RBL-2H3 cells model with IC50 values of 40.1, 6.1 and 18.7 μM, respectively.
Agid:
744230