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Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01

Author:
Kasettrathat, Chairut, Ngamrojanavanich, Nattaya, Wiyakrutta, Suthep, Mahidol, Chulabhorn, Ruchirawat, Somsak, Kittakoop, Prasat
Source:
Phytochemistry 2008 v.69 no.14 pp. 2621-2626
ISSN:
0031-9422
Subject:
Ascomycota, lactones, esters, phytochemicals, chemical structure, spectral analysis, medicinal properties, cytotoxicity, anticarcinogenic activity, Plasmodium falciparum, human health
Abstract:
Nodulisporacid A (1) was isolated from a marine-derived fungus Nodulisporium sp. CRIF1, while vermelhotin (5) was obtained from an unidentified fungus CRI247-01 (a member of the Order Pleosporales). Both 1 and 5 occurred as equilibrium E/Z mixtures. Ester derivatives (2 and 3) and vermelhotin (5) showed cytotoxic activity against eleven cancer cell lines. Nodulisporacid A (1) and vermelhotin (5) exhibited moderate antiplasmodial activity.
Agid:
744231