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Non-cannabinoid constituents from a high potency Cannabis sativa variety
- Radwan, Mohamed M., ElSohly, Mahmoud A., Slade, Desmond, Ahmed, Safwat A., Wilson, Lisa, El-Alfy, Abir T., Khan, Ikhlas A., Ross, Samir A.
- Phytochemistry 2008 v.69 no.14 pp. 2627-2633
- Cannabis sativa, hemp, chemical constituents of plants, phytochemicals, benzoquinones, phenanthrene, palmitates, cannabinoids, chemical structure, spectral analysis, medicinal properties, antifungal properties, antibacterial properties, antioxidant activity, human health
- Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and β-sitosteryl-3-O-β-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, α-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and β-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics.