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Association analysis of the INHA gene with litter size in Boer goats [Erratum: 2009 June, v. 84, no. 1-3, p. 135-136.]
- Wu, Weisheng, Hua, Guohua, Yang, Liguo, Wen, Qunying, Zhang, Chunyan, Zoheir, Khairy M., Chen, Shilin
- Small ruminant research 2009 v.82 no.2-3 pp. 139-143
- parity (reproduction), overdominance, goats, amino acid substitution, female fertility, genes, genotype, inhibin, litter size, females, genetic markers, single nucleotide polymorphism
- This study investigated the association between differences in litter size in Boer does, with genetic polymorphisms in the inhibin alpha gene. Our preliminary (n =209) results found 12 SNPs, including the non-synonymous polymorphisms 911T/C and 946A/C, resulting in corresponding 299V/A and 311T/P amino acid polymorphisms. Of the SNPs, 651A/G was preliminarily suggested as a useful marker for litter size of the second parity in the population studied, showing an overdominance effect. Polymorphisms, sequence, and genotype distributions were also characterized.