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Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate

Bo Song, Zhendong Qiu, Mingxue Li, Tingting Luo, Qi Wu, Hari B. Krishnan, Junjiang Wu, Pengfei Xu, Shuzhen Zhang, Shanshan Liu
Journal of functional foods 2022 v.90 pp. 104979
arginine, beverages, cholesteremic effect, cultivars, fatty liver, fenofibrate, globulins, high density lipoprotein cholesterol, high fat diet, loss-of-function mutation, oral administration, soy protein isolate, soybeans, triacylglycerols
Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF.