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Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)

Author:
Mbaze, Luc Meva'a, Lado, Jean Alexandre, Wansi, Jean Duplex, Shiao, Tze Chieh, Chiozem, David Dako, Mesaik, Muhammad Ahmed, Choudhary, Muhammad Iqbal, Lacaille-Dubois, Marie-Aleth, Wandji, Jean, Roy, Rene, Sewald, Norbert
Source:
Phytochemistry 2009 v.70 no.11-12 pp. 1442-1447
ISSN:
0031-9422
Subject:
Zanthoxylum, bark, amides, lignans, phytochemicals, chemical structure, spectral analysis, antioxidant activity, cytotoxicity, anticarcinogenic activity
Abstract:
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC50 = 2.0-6.5 μM, but no cytotoxic effect was observed (IC50 > 100 μM).
Agid:
767862