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The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs

Sen Zeng, Yuwan Li, Wenhui Zhu, Zipeng Luo, Keke Wu, Xiaowen Li, Yiqi Fang, Yuwei Qin, Wenxian Chen, Zhaoyao Li, Linke Zou, Xiaodi Liu, Lin Yi, Shuangqi Fan
Microorganisms 2022 v.10 no.7 pp. -
Betacoronavirus 1, Infectious bronchitis virus, Middle East respiratory syndrome coronavirus, Murine hepatitis virus, Porcine epidemic diarrhea virus, Severe acute respiratory syndrome coronavirus 2, antiviral agents, chickens, diarrhea, drug therapy, gastroenteritis, humans, immunization, morbidity, mortality, public health, swine, vaccines, viruses
Coronaviruses, mainly including severe acute respiratory syndrome virus, severe acute respiratory syndrome coronavirus 2, Middle East respiratory syndrome virus, human coronavirus OC43, chicken infectious bronchitis virus, porcine infectious gastroenteritis virus, porcine epidemic diarrhea virus, and murine hepatitis virus, can cause severe diseases in humans and livestock. The severe acute respiratory syndrome coronavirus 2 is infecting millions of human beings with high morbidity and mortality worldwide, and the multiplicity of swine epidemic diarrhea coronavirus in swine suggests that coronaviruses seriously jeopardize the safety of public health and that therapeutic intervention is urgently needed. Currently, the most effective methods of prevention and control for coronaviruses are vaccine immunization and pharmacotherapy. However, the emergence of mutated viruses reduces the effectiveness of vaccines. In addition, vaccine developments often lag behind, making it difficult to put them into use early in the outbreak. Therefore, it is meaningful to screen safe, cheap, and broad-spectrum antiviral agents for coronaviruses. This review systematically summarizes the mechanisms and state of anti-human and porcine coronavirus drugs, in order to provide theoretical support for the development of anti-coronavirus drugs and other antivirals.