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Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching

Author:
Zhou, Daonian, Ruan, Jinlan, Cai, Yaling, Xiong, Zhaomei, Fu, Wei, Wei, Anhua
Source:
Journal of ethnopharmacology 2010 v.129 no.2 pp. 232-237
ISSN:
0378-8741
Subject:
Dryopteridaceae, ferns and fern allies, medicinal plants, medicinal properties, antioxidant activity, hepatoprotective effect, plant extracts, ethanol, free radicals, lipid peroxidation, free radical scavengers, mice, animal models, liver, superoxide anion, hydrogen peroxide, oral administration, dosage, aspartate transaminase, liver function, malondialdehyde, superoxide dismutase, alanine transaminase
Abstract:
Aim of the study: The study was aimed to investigate the ethanol extract of Arachniodes exilis for the antioxidant and hepatoprotective activity. Materials and methods: Antioxidant activity was evaluated by different assays, including reducing power, lipid peroxidation, 2, 2′-diphenyl-1-picrylhydrazyl (DPPH), 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), superoxide anion, hydroxyl radicals and hydrogen peroxide. The hepatoprotective activity of ethanol extract was studied on mice liver damage induced by CCL₄ by monitoring biochemical parameters. Results: The extract showed potent activities on reducing power, lipid peroxide, DPPH, ABTS, superoxide anion, hydroxyl radical and hydrogen peroxide. And oral administration of Arachniodes exilis at different doses resulted in significant improvement on the levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, malondialchehyche and superoxidedismutase. Conclusion: The results indicate that this plant possesses potential antioxidant and hepatoprotective properties and has therapeutic potential for the treatment of liver diseases.
Agid:
785196