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Structural requirements for repellency: norsesquiterpenes and sesquiterpenoid derivatives of nootkatone against the Formosan subterranean termite (Isoptera: Rhinotermitidae)

Author:
Zhu, Betty CR, Henderson, Gregg, Sauer, Anne M., Crowe, William, Laine, Roger A.
Source:
Pest management science 2010 v.66 no.8 pp. 875-878
ISSN:
1526-498X
Subject:
Coptotermes formosanus, subterranean termites, insect repellents, chemical structure, structure-activity relationships, sesquiterpenoids, toxicity, synthetic products, assays, chemical concentration, nootkatone
Abstract:
BACKGROUND:Research has shown that the family of grapefruit flavors called nootkatones have significant repellant and toxic effects to Formosan subterranean termites (Coptotermes formosanus Shiraki).RESULTS:Nineteen synthetic nootkatone derivatives, along with three commercially available nootkatone derivatives, were tested for repellent activity against C. formosanus by a choice assay in a petri dish with a two-step triage procedure. Based on the repellency threshold value, the relationships between structure and activity are discussed.CONCLUSION:Four derivatives of nootkatone have very high repellency and toxicity to C. formosanus, 9 times the potency of the primary compound nootkatone. Four other compounds have between 2 and 3 times the repellency of nootkatones, and three compounds are equal in their repellency to nootkatone.
Agid:
788926