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Abarema cochliacarpos: Gastroprotective and ulcer-healing activities

da Silva, Maria Silene, de Almeida, Ana Cristina Alves, de Faria, Felipe Meira, Luiz-Ferreira, Anderson, da Silva, Marcelo Aparecido, Vilegas, Wagner, Pellizzon, Cláudia Helena, Brito, Alba Regina Monteiro Souza
Journal of ethnopharmacology 2010 v.132 no.1 pp. 134-142
Abarema, medicinal plants, medicinal properties, gastritis, stomach ulcers, herbal medicines, plant extracts, fractionation, methanol, chloroform, bark, rats, animal models, gastric juice, protective effect, tissue repair, gastric mucosa, dosage, oral administration, cell proliferation, Brazil
Ethnopharmacological relevance: Abarema cochliacarpos (Gomes) Barneby & Grimes (Mimosaceae) is a species - in folk medicine of Lagarto city, Sergipe state, northeastern Brazil - reputed to heal gastric ulcer and gastritis. Aim of the study: Chloroform (CE) and methanolic (ME) extracts as well as ethyl acetate fraction (AF), butanolic fraction (AC) and aqueous fraction (AQF) of the methanolic extract of Abarema cochliacarpos bark were evaluated against acute gastric ulcer. The AC fraction was selected to assess its activity in ulcer healing and its gastroprotective effects via mucus and gastric secretion. Material and methods: The gastroprotective action of CE and ME extracts and the fractions of the latter were evaluated in a rodent experimental model. The action mechanisms, involvements of the antisecretory action and mucus production, toxicological and healing activity of the AC (150mg/kg, p.o.) were evaluated. We also used histological analysis (HE and PAS) and immunohistochemical (PCNA, COX-2, VEGF and HSP-70) assays to evaluate the effects of Abarema cochliacarpos. Results: CE (200 and 400mg/kg, p.o.) and ME (100, 200 and 400mg/kg, p.o.) extracts were able to protect gastric mucosa against absolute ethanol. Respective inhibitions produced were: 65.31% and 83.80% by the first; 91.69%, 96.75% and 99.80% by the second; and 74.24% by the AC fraction. Antisecretory and mucus production effects were exhibited by the AC fraction, which also accelerated the healing of ulcerated gastric mucosa by stimulating proliferation factors (PCNA) and induced healing factors including COX-2, VEGF and HSP-70. Conclusion: All these results suggest that Abarema cochliacarpos (Gomes) Barneby & Grimes presents gastroprotective effects and wound-healing properties.