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Effect of entrapped α-tocopherol on mucoadhesivity and evaluation of the release, degradation, and swelling characteristics of zein–chitosan composite electrospun fibers
- Wongsasulak, Saowakon, Pathumban, Sunantha, Yoovidhya, Tipaporn
- Journal of food engineering 2014 v.120 pp. 110-117
- alpha-tocopherol, chitosan, composite polymers, ethylene oxide, gastric juice, gastric mucosa, pH, pepsin, scanning electron microscopy, surface area
- A gastro-mucoadhesive matrix of ultrafine fibers was formed from composite polymers of zein, poly(ethylene oxide), and chitosan at a ratio of 87.5/10/2.5 via electrospinning. Alpha-tocopherol (α-TOC), a hydrophobic compound, was embedded at 20wt% into the fiber matrix to investigate its effects on fiber morphology and mucoadhesivity. α-TOC release characteristics were examined in simulated gastric fluid (SGF) at pH 1.2 with pepsin and SGF at pH 2 without pepsin at 37±0.5°C. Gastro-mucoadhesivity was tested in porcine gastric mucosa. Fiber morphology was characterized by scanning electron microscopy (SEM). α-TOC did not affect fiber morphology, but significantly enhanced mucoadhesivity (p<0.05). α-TOC release in SGF at pH 1.2 with pepsin was triggered by erosion, and α-TOC release in SGF at pH 2 without pepsin was triggered by swelling, and driven by diffusion. SEM micrographs revealed that the fibers lost their fibrous structure and later fused, minimizing the fibrous film release surface area.