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Expression analysis of programmed death ligand 2 in tumors caused by the avian oncovirus Marek’s disease virus
- Matsuyama-Kato, Ayumi, Murata, Shiro, Isezaki, Masayoshi, Takasaki, Sarah, Kano, Rika, Konnai, Satoru, Ohashi, Kazuhiko
- Archives of virology 2014 v.159 no.8 pp. 2123-2126
- chickens, messenger RNA, neoplasms, interferon-gamma, coculture, splenocytes, Gallid alphaherpesvirus 2, viruses, death
- PD-L2 is a ligand of the immunoinhibitory receptor PD-1. Here, we report functional and expression analyses of PD-L2 in tumor lesions and spleens from chickens infected with gallid herpesvirus 2 (GaHV-2, Marek’s disease virus), which induces malignant lymphomas in chickens. We show that the expression of IFN-γ protein was decreased in PBMCs and splenocytes co-cultured with PD-L2-expressing cells and that the expression of PD-L2 mRNA was significantly higher in the spleens of infected chickens in the latent phase and in tumor lesions caused by GaHV-2. These results suggest that chicken PD-L2 has an immunoinhibitory function and is involved in the establishment of latency and tumor formation by GaHV-2.