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Anti-hyperglycemic agents from tropical plant extracts
- Palanisamy, U. D., Manahran, T., Masilami, T.
- Acta horticulturae 2014 no.1040 pp. 231-237
- absorption, alpha-amylase, alpha-glucosidase, antioxidant activity, antioxidants, plant extracts, tannins
- Preliminary investigations on 15 plant extracts (ethanolic and aqueous extraction) identified as high antioxidants and having a significant total phenolic content were also seen to have α-amylase and α-glucosidase activity. A correlation between the anti-hyperglycemic activity, total phenolic content and antioxidant (DPPH) activity was established. To further substantiate these findings, known phenolic compounds, its antioxidant activity and α-amylase and α-glucosidase activity were determined. The possibility of tannins binding non-specifically to the enzymes thus contributing to the anti-hyperglycemic activity was also investigated. Our study clearly indicated that anti-hyperglycemic activity observed in the plant extracts was indeed not due to tannins non-specific absorption.