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CLA Supplementation and Aerobic Exercise Lower Blood Triacylglycerol, but Have No Effect on Peak Oxygen Uptake or Cardiorespiratory Fatigue Thresholds

Jenkins, Nathaniel D. M., Buckner, Samuel L., Cochrane, Kristen C., Bergstrom, Haley C., Goldsmith, Jacob A., Weir, Joseph P., Housh, Terry J., Cramer, Joel T.
Lipids 2014 v.49 no.9 pp. 871-880
blood serum, cholesterol, conjugated linoleic acid, education programs, exercise, gas exchange, glucose, humans, isomers, men, oxygen, statistical analysis, sunflower oil, triacylglycerols
This study examined the effects of 6 weeks of conjugated linoleic acid (CLA) supplementation and moderate aerobic exercise on peak oxygen uptake ([Formula: see text] peak), the gas exchange threshold (GET), the respiratory compensation point (RCP), and serum concentrations of cholesterol, triacylglycerol, and glucose in humans. Thirty-four untrained to moderately trained men (mean ± SD; age = 21.5 ± 2.8 years; mass = 77.2 ± 9.5 kg) completed this double-blind, placebo controlled study and were randomly assigned to either a CLA (Clarinol A-80; n = 18) or placebo (PLA; sunflower oil; n = 16) group. Prior to and following 6 weeks of aerobic training (50 % [Formula: see text] peak for 30 min, twice per week) and supplementation (5.63 g of total CLA isomers [of which 2.67 g was c9, t11 and 2.67 g was t10, c12] or 7.35 g high oleic sunflower oil per day), each participant completed an incremental cycle ergometer test to exhaustion to determine their [Formula: see text] peak, GET, and RCP and fasted blood draws were performed to measure serum concentrations of cholesterol, triacylglycerol, and glucose. Serum triacylglycerol concentrations were lower (p < 0.05) in the CLA than the PLA group. For [Formula: see text] peak and glucose, there were group × time interactions (p < 0.05), however, post hoc statistical tests did not reveal any differences (p > 0.05) between the CLA and PLA groups. GET and RCP increased (p < 0.05) from pre- to post-training for both the CLA and PLA groups. Overall, these data suggested that CLA and aerobic exercise may have synergistic, blood triacylglycerol lowering effects, although CLA may be ineffective for enhancing aerobic exercise performance in conjunction with a 6-week aerobic exercise training program in college-age men.